Once prepared, LYMPHOSEEK® is a radioactive drug and should be handled with appropriate safety measures, including effective gloves and shielding, to minimize radiation exposure. Radiopharmaceuticals should be used by or under the control of physicians who are qualified, experienced and licensed by the appropriate governmental agency in the safe use of radionuclides.
Preparation of LYMPHOSEEK
For each patient, the total injection volume and the number of sites to be injected should be known before preparing LYMPHOSEEK.
Each radiolabeled LYMPHOSEEK vial contains sufficient amount to provide doses for up to four patients when prepared according to the instructions. The radiolabeled LYMPHOSEEK is to be used within 6 hours of its preparation.
In animal studies, locally injected anesthetics have been reported to reduce lymphatic flow. Co-injection (mixture) of local anesthetics with LYMPHOSEEK is not recommended and may impair the lymph nodal mapping.
Recommended Dose of LYMPHOSEEK
18.5 MBq (0.5 mCi) radioactivity dose
50 mcg mass dose
Volume of Injection
0.1 mL in 1 syringe
0.5 mL in 1 syringe or multiple syringes (0.1 or 0.25 mL each)
1 mL in multiple syringes (0.2, 0.25 or 0.5 mL each)
Routes of Administration
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Recommended Time from Administration to Lymphatic Mapping